Cellular Mechanism of Gene Mutations and Potential Therapeutic Targets in Ovarian Cancer

Ovarian cancer is a common and complex malignancy with poor prognostic outcome. Most women ovarian are diagnosed advanced stage disease due to lack of effective detection strategies in the early stage. Traditional treatment cytoreductive surgery platinum-based combination chemotherapy has not significantly improved prognosis 5-year survival rates still extremely poor. Therefore, novel needed improve patients. Recent advances next generation sequencing technologies have both confirmed previous known mutated genes discovered candidate cancer. In this review, we illustrate recent identifying gene mutations, including those TP53, BRCA1/2, PIK3CA, KRAS genes. addition, discuss targeting therapies for based on these Further, associate between mutation by liquid biopsy potential diagnostic value